N6-Methyladenine
(mA)
N6-Methyladenine is a methylated base found in prokaryotic DNA. In
E. coli, methylation of A residues in the sequence 5´-GATC-3´
is involved in mismatch error correction, and it plays a role
in controlling initiation of DNA replication. Methylation at other
sites protects DNA against cleavage by restriction endonucleases
(described here).
See also: DNA
Methylation, Prokaryotic Mismatch
Repair, Initiation of
DNA Replication, N4-Methylcytosine
INTERNET LINK:
The
Effect of Site-Specific Methylation on Promega Restriction Enzymes