Outline
Introduction
Interdependence of the Major Organs in Vertebrate Fuel Metabolism
Fuel Inputs and Outputs (Figure 23.1, Table 23.1)
Metabolic Division of Labor Among the Major Organs
Hormonal Regulation of Fuel Metabolism
Actions of the Major Hormones (Table 23.2, Figure 23.2)
Responses to Metabolic Stress: Starvation, Diabetes (Figure 23.4
Starvation (Diagram)
Diabetes (Figure 23.5)
Mechanisms of Hormone Action (Figure 23.6)
An Outline of Hormone Action (Figure 12.13, Figure 13.18, Figure 21.34, Figure 23.7)
Hierarchical Nature of Hormonal Control (Figure 23.8, Figure 23.9)
Synthesis of Hormones: Peptide Hormone Precursors (Figure 5.15, Figure 23.10)
Signal Transduction: Receptors
Experimental Study of Receptors
Classes of Catecholamine Receptors (Table 23.3)
Receptors and Adenylate Cyclase as Distinct Components of Signal Transduction Systems (Figure 23.11)
Signal Transduction: G Proteins
Actions of G Proteins
Structure of G Proteins (Figure 23.12)
Consequences of Blocking GTPase (Diagram 1, #2)
G Proteins in Vision (Diagram)
A Closer Look at G Protein Subunits (Table 23.4)
Second Messenger Systems (Figure 23.14, Diagram 1, #2, Table 23.5)
The Insulin Receptor and Related Receptors with Protein Kinase Activity (Figure 23.15)
Steroid and Thyroid Hormones - Intracellular Receptors (Table 23.6, Figure 23.16, Figure 23.17, Figure 23.18)
Signal Transduction, Oncogenes, and Cancer
Viral and Cellular Oncogenes (Figure 23.19, Table 23.7)
Oncogenes and Cell Signalling (Figure 23.23, Figure 23.24 Table 23.7)