PRPP Amidotransferase

PRPP amidotransferase is an enzyme that catalyzes the reaction below:

PRPP + Glutamine <=> 5-Phosphoribosylamine (PRA) + Glutamate +PPi

PRPP amidotransferase is regulated allosterically by AMP, ADP, GMP, and GDP, which all inhibit the reaction.

See also: Figure 22.4, De Novo Biosynthesis of Purine Nucleotides, The Importance of PRPP