-D-ribosyl-1-pyrophosphate
(PRPP) is an intermediate in both the de novo synthesis
of nucleotides (Figure 22.1) and
the salvage synthesis (reutilization) of nucleotides (Figure
22.2).
5-Phospho--D-ribosyl-1-pyrophosphate
(PRPP) is an intermediate in both the de novo synthesis
of nucleotides (Figure 22.1) and
the salvage synthesis (reutilization) of nucleotides (Figure
22.2).
PRPP is synthesized from ribose-5-phosphate as shown here.
PRPP is converted to a nucleotide by addition of a base, as shown here. This reaction is reversible, but it proceeds almost exclusively to the right in cells, due to the PPi product, which is readily cleaved by phosphodiesterases.
See also: De
Novo Biosynthesis of Purine Nucleotides, PRPP Amidotransferase,
Figure 22.4
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