The first step making porphyrins is synthesis
of
-aminolevulinic
acid (ALA) catalyzed by the pyridoxal phosphate-containing
enzyme,
-aminolevulinic acid synthetase
(ALA synthestase) (Figure 21.28).
In plants, ALA is made in a process that begins with glutamate,
which becomes linked to a tRNA (Figure
21.29). In plants, synthesis of ALA is regulated by light.
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