Phosphatidylglycerol-3-phosphate is an intermediate in synthesis of cardiolipin.
It is made by addition of glycerol-3-phosphate to CDP-diacylglycerol
(Figure 19.4) in the reaction
that follows.
Phosphatidylglycerol-3-phosphate is an intermediate in synthesis of cardiolipin.
It is made by addition of glycerol-3-phosphate to CDP-diacylglycerol
(Figure 19.4) in the reaction
that follows.
CDP-Diacylglycerol + Glycerol-3-Phosphate (or Myoinositol or Serine) <=> Phosphatidylglycerol-3-Phosphate (or Phosphatidylinositol or Phosphatidylserine) + CMP
Subsequently, the external phosphate is hydrolyzed to make phosphatidylglycerol, which is then joined with another phosphatidylglycerol to make cardiolipin (Figure 19.4).