Malonyl-CoA

Malonyl-CoA is an intermediate in fatty acid biosynthesis. It is produced in the reaction that follows (Figure 18.24):

Acetyl-CoA + ATP + HCO3- <=> Malonyl-CoA + ADP + Pi + H+

Subsequently, Malonyl-CoA is converted to malonyl-ACP in the next reaction of fatty acid biosynthesis:

Malonyl-CoA + ACP <=> Malonyl-ACP + CoASH (catalyzed by Malonyl-CoA-ACP transacylase.)

See also: Fatty Acid Biosynthesis Strategy, Fatty Acid Synthase, Fatty Acids, Palmitate Synthesis from Acetyl-CoA, Synthesis of Long Chain Fatty Acids, Figure 18.27

INTERNET LINK: Fatty Acid Biosynthesis