HMG-CoA Lyase

HMG-CoA lyase is a mitochondrial enzyme responsible for catalyzing the reaction below:

-Hydroxy--Methylglutaryl-CoA (HMG-CoA) <=> Acetyl-CoA + Acetoacetate

This reaction is a step in the formation of ketone bodies (See Figure 18.21). Notably, HMG-CoA is also an intermediate in cholesterol biosynthesis, whcih occurs in the cytoplasm