Apo C-II is a polypeptide of molecular weight 10,000 found primarily in VLDLs and, to a lesser extent, in chylomicrons (Table 18.1). Apo C-II activates Lipoprotein Lipase. A human deficiency of Apo C-II is associated with elevated triacylglycerol levels in blood. Apo E is also found in the Apo C-II gene cluster.