2,4-dienoyl-CoA reductase is an enzyme essential for
oxidation of
unsaturated fatty acids. It catalyzes the formation of cis-
3-enoyl-CoA from trans-
2-cis-
4-enoyl-CoA (Reaction #5, Figure
18.18).
Along with the enzyme enoyl-CoA isomerase, 2,4-dienoyl-CoA reductase permits unsaturated fatty acids in the diet containing cis double bonds to be catabolized.