Fructose-1,6-Bisphosphatase (F1,6BPase)

F1,6BPase is an enzyme in gluconeogenesis that catalyzes hydrolysis of fructose-1,6-bisphosphate, producing fructose-6-phosphate and Pi.

Fructose-1,6-Bisphosphate + H2O <=> Fructose-6-Phosphate + Pi

F1,6BPase is a key regulatory enzyme of gluconeogenesis. It is allosterically inactivated by fructose-2,6-bisphosphate and AMP (Figures 16.6 and 16.7). Synthesis of F1,6BPase is also regulated hormonally.

See also: Regulation of Gluconeogenesis, Fructose-2,6-Bisphosphate in Gluconeogenesis Regulation, Gluconeogenesis Enzymes, Glycolysis Enzymes, AMP