Malic Enzyme (officially named malate dehydrogenase-decarboxylating: NADP+) catalyzes the reaction below.

Pyruvate + HCO3^- + NADPH + H⁺ <=> L-Malate +  NADP+ + H2O

This important anaplerotic reaction provides a means of replenishing L-malate in the citric acid cycle (Figure 14.18) and it also plays an important role in the citrate shuttle (Figure 18.31).