Isocitrate dehydrogenase is an enzyme of the citric acid cycle that catalyzes the reaction below (reaction diagram)

Isocitrate + NAD⁺ <=> -Ketoglutarate + CO2 + NADH ( = -20.9 kJ/mol)

An  NADP+ specific form of the enzyme is present in both cytosol and mitochondria.

Isocitrate dehydrogenase is an allosteric control point in the citric acid cycle. In many cells, isocitrate dehydrogenase is activated by ADP and inhibited by NADH.

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