Fumarate Hydratase (Fumarase)

Fumarase is an enzyme of the citric acid cycle, glyoxylate cycle, and urea cycle that catalyzes addition of water to the double bond of fumarate to form L-malate.

Fumarate + H2O <=> L-Malate ( = -3.8 kJ/mol).

The enzyme is stereospecific, working only on the trans isomer.

Next enzyme of citric acid cycle / Previous enzyme of cycle

See also: Enzymes of the citric acid cycle, Intermediates of the Citric Acid Cycle, Pathway of the Citric Acid Cycle, Table 14.1

INTERNET LINKS:

1. Glyoxylate Cycle Metabolism

2. Citric Acid Cycle

3. Urea Cycle and Metabolism of Amino Groups