Cis-Aconitate

Cis-aconitate is an intermediate in synthesis of isocitrate from citrate in the citric acid cycle. The enzyme catalyzing the reaction is aconitase.

Cis-aconitate is transiently formed as a product bound to the enzyme. The compound is formed from citrate by removal of a water, which is added back to obtain isocitrate (reaction diagram).

See also: Intermediates of the Citric Acid Cycle, Figure 14.3, Table 14.1, Fluoroacetate, Fluorocitrate

INTERNET LINKS:

1. Glyoxylate Cycle Metabolism

2. Citric Acid Cycle