CDP is also linked to a phosphorylated form of choline to form CDP-choline in the predominant mechanism of phosphatidylcholine synthesis (Figure 19.5). Oxidation of choline to glycine betaine is one mechanism of donating a methyl group in biosynthesis of methionine (see here).

Sphingomyelin is made by transferring choline from phosphatidylcholine to a ceramide (Figure 19.13).

Other reactions involving choline:

1. Choline + Acetyl-CoA <=> Acetylcholine + CoASH (catalyzed by Choline Acetyltransferase)

2. Acetylcholine + H2O <=> Choline + Acetate (catalyzed by Acetylcholinesterase)

3. Choline + ATP <=> Phosphocholine + ADP (catalyzed by Choline Kinase)