The most common cerebrosides include galactosylceramide, glucosylceramide, and sulfatides (see Figure 19.14 for synthesis scheme). Sulfatides are made by transferring a sulfate group to a galactosylceramide (Figure 19.14).
Deficiencies in enzymes involved in catabolism
of cerebrosides lead to sphingolipidosis. These give rise
to the following diseases - Gaucher's Disease (deficiency of
-glucosidase -#4), Globoid cell leukodystrophy (deficiency of
galactosidase - #7), and metachromatic leukodystrophy (deficiency of
arylsulfatase A - #8). These enzymes are depicted in Table
19.1 and Figure 19.16
consistent with the numbers shown in red above.
See also: Sphingolipids, Glycosphingolipids, Gangliosides, Sialic Acid, Globosides