Outline

Introduction (Figure 6.1)

Secondary Structure: Regular Ways to Fold the Polypeptide Chain

Discovery of Regular Polypeptide Structures (Figure 5.12b, Figure 6.2, Figure 6.3, Figure 6.4)

Describing the Structures: Molecular Helices and Pleated Sheets (Figure 6.5, Figure 6.6, Table 6.1)

Ramachandran Plots (Figure 6.2, Figure 6.8, Figure 6.9, Figure 6.10)

Fibrous Proteins: Structural Materials of Cells and Tissues (Table 6.2)

The Keratins (Figure 6.11)

Fibroin (Figure 6.12, Table 6.2)

Collagen

Collagen Structure (Figure 6.13, Figure p. 179)
Collagen Synthesis (Figure 6.14)

Elastin (Unnumbered Figure)

Globular Proteins: Tertiary Structure and Functional Diversity

Different Folding for Different Functions (Figure 6.1, Figure 6.16)

Varieties of Globular Protein Structure: Patterns of Folding (Figure 6.16, Figure 6.17, Figure 6.18, Figure 6.19)

Factors Determining Secondary and Tertiary Structure

The Information for Protein Folding (Figure 6.20)

The Thermodynamics of Folding

Conformational Entropy
Charge-Charge Interactions
Internal Hydrogen Bonds (Figure 6.21)
van der Waals Interactions (Table 6.3)
The Hydrophobic Effect (Table 6.4, Figure 6.22)

The Role of Disulfide Bonds (Figure 6.23)

Dynamics of Globular Protein Structure

Kinetics of Protein Folding (Figure 6.24)

Kinetics of Disulfide Bond Formation (Figure 6.25)

Chaperonins (Figure 6.26)

Motions Within Globular Protein Molecules (Table 6.5)

Prions - Protein Folding and Mad Cow Disease (Figure 6.27)

Prediction of Secondary and Tertiary Protein Structure

Prediction of Secondary Structure (Table 6.6, Figure 6.28)

Tertiary Structure: Computer Simulation of Folding

Quaternary Structure of Proteins (Figure 6.29)

Multisubunit Proteins: Homotypic Protein-Protein Interactions (Figure 6.30, Figure 6.32, Figure 6.33)

Heterotypic Protein-Protein Interactions